Prof. Emeritus Chun-Pin Chiang
Oral pathology, oral histology, immunohistochemistry, photodynamic therapy
23123456 ext 267407
- B.D.S., Dentistry, National Taiwan University, 1977
- D.M.Sc., Oral Pathology, Harvard School of Dental Medicine, 1989
- Immunohistochemical Studies of Oral Lesions:
This study primarily utilizes monoclonal or polyclonal antibodies and immunohistochemical staining to investigate the expression of oncogenes, tumor suppressor genes, growth factors, growth factor receptors, and cytokeratins in oral precancerous lesions, oral cancer, salivary gland tumors, odontogenic cysts, and odontogenic tumors. It further explores the correlation between the expression of these specific proteins and oral habits, clinical parameters (patient gender, age, tumor location, tumor size, lymph node metastasis, clinical staging), and histopathological parameters. This research will greatly contribute to the understanding of the malignant potential of oral precancerous lesions and the pathogenic mechanisms of oral lesions. - Photodynamic Diagnosis and Treatment of Oral Precancerous and Cancerous Lesions:
In recent years, we have developed autofluorescence spectroscopy and dye fluorescence spectroscopy (5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy) to assist in the diagnosis of oral precancerous and cancerous lesions. Our research has found that autofluorescence spectroscopy measured with 330 nm excitation light and ALA-induced PpIX fluorescence spectroscopy measured with 410 nm excitation light can help differentiate oral submucous fibrosis (OSF), normal oral mucosa, oral precancerous lesions, and oral cancer. Therefore, using this autofluorescence and dye fluorescence spectroscopy technology, it is possible to determine the appropriate biopsy site in a wide range of oral leukoplakia or erythroplakia lesions. Additionally, topical application of 20% ALA in photodynamic therapy can also serve as an adjuvant treatment for oral precancerous lesions and oral cancer, which is very effective in treating verrucous hyperplasia and erythroleukoplakia, while also having great potential for treating verrucous carcinoma and early-stage oral cancer.
- Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM, Chiang CP (2016). Do all the patients with vitamin B12 deficiency have pernicious anemia? Journal of Oral Pathology & Medicine 45:23-7.(SCI)
- Sun A, Chang JYF, Chiang CP (2016). Blood examination is necessary for oral mucosal disease patients. Journal of the Formosan Medical Association 115:1-2.(SCI)
- Cheng SJ, Chen HM and Chiang CP (2015). Cryogun cryotherapy is the first-line treatment of choice for oral leukoplakia. Journal of Dental Sciences 10: 223-224. (SCI)
- Chiang ML, Hsieh YJ, Tseng YL, Lin JR and Chiang CP (2014). Oral mucosal lesions and developmental anomalies in dental patients of a teaching hospital in Northern Taiwan. Journal of Dental Sciences 9: 69-77. (SCI)
- Shen WR, Wang YP, Chang JYF, Yu SY, Chen HM and Chiang CP (2014). Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine 43: 258-264. (SCI)
- Sun A, Lin HP, Wang YP, Chen HM, Cheng SJ, Chiang CP (2013). Significant reduction of serum homocysteine level and oral symptoms after different vitamin supplement treatments in patients with burning mouth syndrome. Journal of Oral Pathology & Medicine doi: 10.1111/jop.12043 (SCI)
- Cheng SJ, Liu YC, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MYP, Chiang CP (2013). Expression of G�12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine DOI: 10.1111/jop.12050. (SCI)
- Lee JJ, Cheng SJ, Wang YP, Jeng JH, Chiang CP, Kok SH (2013). Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases. Head & Neck 35(1):E6-E10. (SCI)
- Cheng SJ, Kok SH, Lee JJ, Kuo MYP, Cheng SL, Huang YL, Chen HM, Chang HH, Chiang CP (2012). Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 34(9):1340-45. (SCI)
- Sun AD, Lin HP, Wang YP, Chiang CP (2012). Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. Journal of Oral Pathology & Medicine 41(6):500-04. (SCI)
