Research Areas
Research Areas and Facilities of the Institute
Oral Biological Science is an interdisciplinary and integrative field. Building upon the Institute’s existing framework of interaction between basic and clinical sciences, we are committed to strengthening interdisciplinary research in order to achieve research outcomes at an international level and, ultimately, to improve the diagnosis and treatment of common oral diseases in the population.
The Institute's planned key areas of development are as follows:
- Translational medical research integrating basic and clinical dentistry
- Research on novel biomedical materials and tissue engineering
- Investigation of the mechanisms and treatment of major oral diseases, including oral cancer and periodontal disease
- Development and application of oral regenerative medicine
The Institute's current major research areas include:
- Research on the carcinogenic mechanisms of betel nut
- Development and application of chemopreventive and therapeutic drugs for oral cancer
- Research on oral cancer stem cells and pathogenic mechanisms
- Research on human stem cells and tissue regeneration
- Research on potassium ion channels and the structural biology of related proteins
- Development and application of oral biomaterials and nanobiomaterials for drug delivery
- Identification of novel periodontitis-associated pathogens using third-generation nanopore sequencing
- Relationships between oral microorganisms and oral as well as systemic diseases
- Investigation of the critical roles of tight junction proteins in mucosal repair and cancer pathogenesis
- Application, technology development, and mechanistic study of therapeutic medical ultrasound in the treatment of oral diseases
At present, dental and medical research institutions in advanced healthcare countries around the world regard fundamental molecular biological research in oral biological science as an indispensable component in the development of dentistry. Institutes of oral biomedicine in the United States, Europe, and Japan are all devoted to integrating basic and clinical dental research. Training doctoral talent in oral biological science with expertise in clinical practice and management has become a global trend. Current academic research mainly focuses on novel biomedical materials and tissue engineering, mechanistic investigation and treatment of major oral diseases such as oral cancer and periodontal disease, as well as the development and application of oral regenerative medicine.
Cell Culture
Researchers used an inverted optical microscope to observe and photograph cell cultures for research
Spread plating
Students are performing plate cultures of periodontitis-associated bacteria
Labelling the specific gene
The student is learning how to track the growth of mucosal epithelial cells in which a specific gene has been labeled with green fluorescence
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