Prof. Jane Chung-Chen Yao

• 國立台灣大學牙醫學士，民國七十八年

• 美國加州大學舊金山分校博士，民國八十六年

• 齒顎矯正、口腔生物、細胞生物

Response Rate of Tissues and Cells to Mechanical Forces

Orthodontic forces stimulate periodontal tissue response resulting in tooth movement via dentoalveolar bone resorption and deposition under mechanical loading, changes of permeability and oxygen supply. The magnitude and frequency characteristics of these forces, as well as the factors influencing the rate of tooth displacement, remain largely unknown in orthodontics. Identifying early biomarkers to detect the rate of tooth movement in orthodontic patients, or key factors triggering multiple downstream gene expressions, could provide insights into the bone remodeling under mechanical stress. This would help to determine the optimal force magnitude and frequency for regulating these changes and identify clusters of genes influenced by mechanical stress. Clinically, this research could lead to predict rate of tooth movement or develop strategies to shorten orthodontic total treatment time. Such advancements would improve quality of life, reduce the high costs of treatment, and lower the risk of dental caries or periodontal disease caused by the difficulty of maintaining oral hygiene during treatment.

Genetic Association Analysis of Mandibular Condylar Bone Resorption Induced by Temporomandibular Joint Osteoarthritis

Degenerative resorption of the mandibular condyle often leads to open bites. Follow-up studies on orthodontic cases using orthodontic mini-implants have shown that treatment outcomes are generally stable with improved occlusion. However, in some cases, persistent degenerative resorption of the condyle has been observed, leading to impairing occlusal function. Conducting genetic association studies by collecting saliva DNA from patients with condylar degeneration could further clarify the mechanisms of mandibular condylar bone resorption. In the future, this research may contribute to breakthroughs in the prediction and treatment strategies for temporomandibular joint osteoarthritis.