Prof. Jiiang-Huei Jeng

Education

• DDS, Dentistry, National Taiwan University, 1985 
• PhD, Dentistry, National Taiwan University, 1994

Experience

• Diplomate of Academy of Endodontology, ROC
• Diplomate of Academy of Periodontology, ROC

Betel quld chewing and oral mucosal diseases

To clarify the effects of areca nut and arecoline on the cellular biological activities and inflammatory responses of oral mucosal cells and associated signal transduction may facilitate our understanding the mechanisms of betel quid carcinogenesis and possible chemoprevention in the future.

Growth factors on the behavior of human dental pulp and periodontal (stem) cells

Growth factors are important during the development of human dental pulp and periodontium. In addition, they can regulate the repair and regeneration of human dental pulp and periodontal tissues following injury. Clarifying the effects of growth factors on the metabolism and behavior of pulp and periodontal (stem) cells will be increasingly important for clinical vital pulp therapy and periodontal regeneration.

Toxicology and pharmacology of various dental materials

Various dental medicaments, materials and their components were tested for the cytotoxicity, genotoxicity, mutagenicity, inflammatory mediator release, and its effect on systemic health. The related toxic mechanisms such as cell cycle, redox changes, apoptosis, and the gene alterations by the toxic ingredients were also evaluated. Results are useful for our safety selection of dental materials for clinical treatment.

Clinical studies

Study the various patterns of crown and root fractures as well as treatment prognosis.

1. Chang MC, Chang SH, Tsai YL, Pan YH, Yeung SY, Chang HH, Jeng JH (2025). Inducing phospholipase A2 and cyclooxygenase-2 expression and prostaglandins’ production of human dental pulp cells by activation of NOD receptor and its downstream signaling. International Journal of Biological Macromolecules 292:139193.
2. Chang MC, Chen JH, Lee HN, Chen SY, Zhong BH, Dhingra K, Pan YH, Chang HH, Chen YJ, Jeng JH (2023). Inducing cathepsin L expression/production, lysosomal activation, and autophagy of human dental pulp cells by dentin bonding agents, camphorquinone and BisGMA and the related mechanisms. Biomaterials Advances 145:213253. (SCI)
3. Chang MC, Wang TM, Chien HH, Pan YH, Tsai YL, Jeng PY, Lin LD, Jeng JH (2022) Effect of butyrate, a bacterial by-product, on the vialibity and ICAM-1 expression/production of human vascular endothelial cells: role in infectious pulpal/periapical diseases. International Endodontic Journal 55:38-53. (SCI)
4. Chang MC, Chen NY, Chen JH, Huang WL, Chen CY, Huang CC, Pan YH, Chang HH, Jeng JH (2022). bFGF stimulated plasminogen activation factors, but inhibited alkaline phosphatase and SPARC in stem cells from apical papilla: involvement of MEK/ERK, TAK1 and p38 signaling. Journal of Advanced Research 40:95-107. (SCI)
5. Chang MC, Pan YH, Wu HL, Lu YJ, Lias WC, Yeh CY, Lee JJ, Jeng JH (2019). Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-b/Smad2-dependent and -independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin. Aging 11:11624-11639. (SCI)
6. Liao WC, Tsai YL, Wang CY, Chang MC, Huang WL, Lin HJ, Liu HC, Chan CP, Chang SH and Jeng JH (2017). Clinical and radiographic characteristics of vertical root fractures in endodontically and nonendodontically treated teeth. Journal of Endodontics 43: 687-693. (SCI)
7. Chang YC, Chang MC, Chen YJ, Liou JU, Chang HH, Huang WL, Liao WC, Chan CP, Jeng PY and Jeng JH (2017). Basic Fibroblast Growth Factor Regulates Gene and Protein Expression Related to Proliferation, Differentiation, and Matrix Production of Human Dental Pulp Cells. Journal of Endodontics 43: 936-942. (SCI)
8. Chang MC, Tsai YL, Chang HH, Lee SY, Lee MS, Chang CW, Chan CP, Cheng RH, Jeng JH (2016). IL-1beta-induced MCP-1 expression and secretion of human dental pulp cells is related to TAK1, MEK/ERK and PI3K/Akt signaling pathways. Archives of Oral Biology 61:16-22. (SCI)
9. Huang CC, Chang YC, Chuang MC, Lin HJ, Tsai YL, Chang SH, Chen JC and Jeng JH (2014). Analysis of the Width of Vertical Root Fracture in Endodontically Treated Teeth by 2 Micro-Computed Tomography Systems. Journal of Endodontics 40: 698-702. (SCI)