侯欣翰 副教授

學歷

• 台北醫學大學保健營養學系學士  民國九十年

• 台灣大學口腔生物科學研究所碩士  民國九十二年

• 陽明大學生理學研究所博士  民國一百零一年

經歷

• 中央研究院生物醫學科學研究所國防役研究助理 (93.01-97.01)

• 台灣大學醫學院內科博士後研究學者 (101.06-108.07)

• 台大醫院牙科部兼任助理研究員(109.08-NOW)

• 台大醫學院牙醫學系兼任助理教授 (110.02-NOW)

• 台大醫學院臨牙所兼任助理教授(110.02-NOW)

1. 利用第三代ONT定序系統分析口腔微生物組成。

2. 探討口腔微生物失衡導致牙周炎及口腔癌的病理機轉。

3. 探討口腔微生物導致肺部疾病的病理機轉。

4. 探討牙科局部麻醉用藥導致過敏反應成因。

1. Chen YF, Chang CL, Hou HH, Chien N, Lu KZ, Chen YY, Hung ZC, Hsiao YH, Sheu CC, Wang PH, Hsieh MH, Hsu WH, Chen MT, Ou WF, Wei YF, Yang TM, Lan CC, Wang CY, Lin CB, Lin MS, Wang YT, Lin CH, Liu SF, Cheng MH, Cheng WC, Peng CK, Chan MC, Chen CY, Jao LY, Wang YH, Chen CJ, Chen SP, Tsai YH, Cheng SL, Lin HC, Chien JY, Wang HC, Yu CJ. The impact of COPD-bronchiectasis association on clinical outcomes: insights from East Asian cohorts validating the ROSE criteria. ERJ Open Res. 2025 Mar 10;11(2):00626-2024.
2. Ko HH, Chou HE, Hou HH, Kuo WT, Liu WW, Yen-Ping Kuo M, Cheng SJ. Oleanolic acid inhibits aldo-keto reductase family 1 member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines. J Dent Sci. 2025 Jan;20(1):100-108.
3. Ko HH, Peng HH, Chou HE, Hou HH, Liu WW, Kuo MY, Lee AY, Kao HF, Lin HY, Chang YC, Kuo WT, Cheng SJ. Downregulation of PAX1 in OSCC Enhances Stemness and Immunosuppression via IFIT1 and PD-L1 Pathways. Oral Dis. 2025 Jan 2. doi: 10.1111/odi.15225.
4. Chen YW, He AC, Huang TY, Lai DH, Wang YP, Liu WW, Kuo WT, Hou HH, Cheng SJ, Lee CY, Chuang WC, Chang CC, Lee BS. Iontophoresis-Enhanced Buccal Delivery of Cisplatin-Encapsulated Chitosan Nanoparticles for Treating Oral Cancer in a Mouse Model. Int J Nanomedicine. 2024 Oct 16;19:10435-10453.
5. Chen YF, Hou HH, Chien N, Lu KZ, Chen YY, Hung ZC, Chien JY, Wang HC, Yu CJ. Type 2 Biomarkers and Their Clinical Implications in Bronchiectasis: A Prospective Cohort Study. Lung. 2024 Jun 17. doi: 10.1007/s00408-024-00707-0.
6. Chen YF, Hou HH, Chien N, Lu KZ, Lin CH, Liao YC, Lor KL, Chien JY, Chen CM, Chen CY, Cheng SL, Wang HC, Hsueh PR, Yu CJ. The clinical impacts of lung microbiome in bronchiectasis with fixed airflow obstruction: a prospective cohort study. Respir Res. 2024 Aug 14;25(1):308.
7. Yu PS, Tu CC, Wara-Aswapati N, Wang CY, Tu YK, Hou HH, Ueno T, Chen IH, Fu KL, Li HY, Chen YW. Microbiome of periodontitis and peri-implantitis before and after therapy: Long-read 16S rRNA gene amplicon sequencing. J Periodontal Res. 2024 May 8.
8. Lizama, JH Chen, CJ Chang, WC Ye, YM Mahmoudi, M Alvarado, NAS Hou HH Tseng, HY. Planarized through-hole valves enabling multilayered microfluidic architecture towards pipette-free ELISA. Microchem J. 2024 Mar 21. 200.110373.
9. Lu KY, Cheng LC, Hung ZC, Chen ZY, Wang CW, Hou HH*. The Ethyl Acetate Extract of Caulerpa microphysa Promotes Collagen Homeostasis and Inhibits Inflammation in the Skin. Curr Issues Mol Biol. 2024 Mar 21;46(3):2701-2712. (*corresponding author)
10. Chen YW, Chiang T, Chen IH, Yuh DY, Tseng HY, Wang CW, Hou HH*. Titanium Surfaces with a Laser-Produced Microchannel Structure Enhance Pre-Osteoblast Proliferation, Maturation, and Extracellular Mineralization In Vitro. Int J Mol Sci. 2024 Mar 16;25(6):3388. (*corresponding author)
11. Chen YW, Hou YW, Wang CW, Cheng SJ, Lin CP, Hou HH*. Oral Lactobacillus zeae exacerbates the pathological manifestation of periodontitis in a mouse model. Mol Oral Microbiol. 2024 Oct;39(5):344-353. (*corresponding author)
12. Shie WY, Cheng SJ, Chen KC, Tang CC, Peng HH, Ko HH, Hou HH, Elizabeth Chou HY. Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma. J Formos Med Assoc. 2023 Sep 11:S0929-6646(23)00333-9.
13. Ko HH, Peng HH, Cheng AN, Chou HE, Hou HH, Kuo WT, Liu WW, Kuo MY, Lee AY, Cheng SJ. Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma. Cancer Sci. 2023 Oct;114(10):3857-3872.
14. Hou HH*, Lee BS, Liu YC, Wang YP, Kuo WT, Chen IH, He AC, Lai CH, Tung KL, Chen YW. Vapor-Induced Pore-Forming Atmospheric-Plasma-Sprayed Zinc-, Strontium-, and Magnesium-Doped Hydroxyapatite Coatings on Titanium Implants Enhance New Bone Formation-An In Vivo and In Vitro Investigation. Int J Mol Sci. 2023 Mar 3;24(5):4933. (*first author)
15. Wang CW, Lin WC, Chen WT, Chen CB, Lu CW, Hou HH, Hui RC, Wu J, Chang CJ, Chang YC, Chung WH; Taiwan Severe Cutaneous Adverse Reaction Consortium. Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population. Front Pharmacol. 2022 Nov 25;13:954596.
16. Chen YW, Wu GH, Lee BS, Liu CT, Li HY, Cheng SJ, Kuo WT, Jeng JH, Chang PC, Lin CP, Chou HYE, Hou HH* Third-generation sequencing-selected Scardovia wiggsiae promotes periodontitis progression in mice. J Periodontal Res. 2023 Feb;58(1):155-164. (*corresponding author)
17. Tseng HY, Lizama JH, Alvarado NAS, Hou HH*. Lab-on-PCB: One step away from the accomplishment of μTAS? Biomicrofluidics. 2022 Jun 24;16(3):031302. (*co-first author)
18. Tseng HY, Chen YW, Lee BS, Chang PC, Wang YP, Lin CP, Cheng SJ, Kuo Mark YP and Hou HH*. The neutrophil elastase-upregulated placenta growth factor promotes the pathogenesis and progression of periodontal disease. J Periodontol. 2022 Sep;93(9):1401-1410. (*corresponding author)
19. Yu WH, Wu E, Li Y, Hou HH, Yu SC, Huang PT, Kuo WH, Qi D, Yu CJ. Matrix Metalloprotease-7 Mediates Nucleolar Assembly and Intra-nucleolar Cleaving p53 in Gefitinib-Resistant Cancer Stem Cells. iScience. 2020 Sep 23;23(10):101600.
20. Lu HH, Lin SY, Weng RR, Juan YH, Chen YW, Hou HH, Hung ZC, Oswita GA, Huang YJ, Guu SY, Khoo KH, Shih JY, Yu CJ, Tsai HC. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma. EBioMedicine. 2020 Jul;57:102846.
21. Hou HH*, Pan HJ, Liao WY, Lee CH, Yu CJ. Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells. Int J Cancer. 2020 Nov 1;147(9):2587-2596. (*first author)
22. Hou HH, HC Wang, SL Cheng, YF Chen, KZ Lu and CJ Yu. MMP-12 activates protease activated receptor (PAR)-1, upregulates placenta growth factor and leads to pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315:L432-42. (*first author)
23. Hou HH, Liao YJ, Hsiao SH, Shyue SK and Lee TS. Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase. Sci Rep. 2015 Aug 25;5:13524. (*first author)
24. Chung KP, Chang HT, Lo SC, Chang LY, Lin SY, Cheng A, Huang YT, Chen CC, Lee MR, Chen YJ, Hou HH, Hsu CL, Jerng JS, Ho CC, Huang MT, Yu CJ and Yang PC. Severe Lymphopenia is Associated with Elevated Plasma Interleukin-15 Levels and Increased Mortality during Severe Sepsis. Shock 2015 Jun; 43 (6):569-75.
25. Hou HH, Cheng SL, Chung KP, Wei SC, Tsao PN, Lu HH, Wang HC, and Yu CJ. PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema. Resp Res. 2014 Sep 5; 15: 106. (*first author)
26. Liao WY, Ho CC, Hou HH, Hsu TH, Tsai MF, Chen KY, Chen HY, Lee YC, Yu CJ, Lee CH and Yang PC. Heparin Cofactor II Enhances Cell Motility and Promotes Metastasis in Non-Small-Cell Lung Cancer. J of Pathol. 2015 Jan; 235(1):50-64.
27. Hou HH, Cheng SL, Chung KP, Kuo YP, Yeh CC, Chang BE, Lu HH, Wang HC and Yu CJ. Elastase induces lung epithelial cells autophagy through placenta growth factor: a new insight of emphysema pathogenesis. Autophagy 2014 Sep; 10: 1509-1521. (*first author)
28. Hou HH, Cheng SL, Liu HT, Yang FZ, Wang HC, Yu CJ. Elastase induced lung epithelial cell apoptosis and emphysema through placenta growth factor. Cell Death Dis. 2013 Sep 5; 4: e793. (*first author)
29. Ching LC, Chen CY, Su KH, Hou HH, Shyue SK, Kou YR, Lee TS. Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase. Mol Med. Mol Med. 2012;18:805-15.
30. Hou HH, Hammock BD, Su KH, Morisseau C, Kou YR, Imaoka S, Oguro A, Shyue SK, Zhao JF, Lee TS. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 2012 Jan 1; 93(1):120-9. (*first author)
31. Su KH, Yu YB, Hou HH, Zhao JF, Kou YR, Cheng LC, Shyue SK, Lee TS. AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase. J Cell Physiol. 2012 Aug; 227(8):3053-62.
32. Su KH, Tsai JY, Kou YR, Chiang AN, Hsiao SH, Wu YL, Hou HH, Pan CC, Shyue SK, Lee TS. Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovasc Res. 2009 Jun 1; 82(3):468-75.
33. Lin H, Cheng CF, Hou HH, Lian WS, Chao YC, Ciou YY, Djoko B, Tsai MT, Cheng CJ, Yang RB. Disruption of guanylyl cyclase-G protects against acute renal injury. J Am Soc Nephrol. 2008 Feb; 19(2):339-48.
34. Pang PH, Lin YH, Lee YH, Hou HH, Hsu SP, Juan SH. Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells. J Cell Physiol. 2008 Apr; 215(1):161-71.
35. Lin H, Hou CC, Cheng CF, Chiu TH, Hsu YH, Sue YM, Chen TH, Hou HH, Chao YC, Cheng TH, Chen CH. Peroxisomal proliferator-activated receptor-alpha protects renal tubular cells from doxorubicin-induced apoptosis. Mol Pharmacol. 2007 Nov; 72(5):1238-45.
36. Lin H, Lee JL, Hou HH, Chung CP, Hsu SP, Juan SH. Molecular mechanisms of the antiproliferative effect of beraprost, a prostacyclin agonist, in murine vascular smooth muscle cells. J Cell Physiol. 2008 Feb; 214(2):434-41.
37. Hou HH, Kuo MY, Luo YW, Chang BE. Recapitulation of human betaB1-crystallin promoter activity in transgenic zebrafish. Dev Dynam. 2006 Feb; 235(2):435-43. (*first author)