周涵怡 副教授

• 國立臺灣大學醫學院分子醫學研究所博士

以螢光奈米鑽石發展之奈米載體與生物系統間的交互作用

近年來奈米材料在生物醫學領域方面的應用日益廣泛多元，本研究著重於探討利用螢光奈米鑽石做為載體攜帶及運送生物材料及遺傳物質之效果，並且探討利用其物理特性運送物質進入生物系統之效率以及交互作用，並做進一步的追蹤觀察，期望能夠增加奈米載體在生醫領域方面的應用

1. Shen LTW, Chou HYE and Kato M (2017). TIF1 beta is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism. Biochemical and Biophysical Research Communications 492(3): 310-315.(SCI)
2. Liu HY, Chen CC, Lin YY, Chen YJ, Liu BH, Wong SC, Wu CY, Chang YT, Chou HYE and Ding ST (2017). Chitosan-assisted differentiation of porcine adipose tissue-derived stem cells into glucose-responsive insulin-secreting clusters. Plos One 12(3). (SCI)
3. Yu IF, Yu YH, Chen LY, Fan SK, Chou HYE and Yang JT (2014). A portable microfluidic device for the rapid diagnosis of cancer metastatic potential which is programmable for temperature and CO2. Lab on a Chip 14(18): 3621-3628. (SCI)
4. Huang CJ, Fang WF, Ke MS, Chou HYE and Yang JT (2014). A biocompatible open-surface droplet manipulation platform for detection of multi-nucleotide polymorphism. Lab on a Chip 14(12): 2057-2062. (SCI)
5. Chen WJ, Ho CC, Chang YL, Chen HY, Lin CA, Ling TY, Yu SL, Yuan SS, Chen YJL, Lin CY, Pan SH, Chou HYE, Chen YJ, Chang GC, Chu WC, Lee YM, Lee JY, Lee PJ, Li KC, Chen HW and Yang PC (2014). Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nature Communications 5. (SCI)
6. Yang YC, Chou HYE, Shen TL, Chang WJ, Tai PH and Li TK (2013). Topoisomerase II-Mediated DNA Cleavage and Mutagenesis Activated by Nitric Oxide Underlie the Inflammation-Associated Tumorigenesis. Antioxidants & Redox Signaling 18(10): 1129-1140. (SCI)
7. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EHH, Wang JS, Hong CY (2012). Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Rheumatology 51(11):1953-65. (SCI)
8. Ho MH, Chiang CP, Liu YF, Kuo MYP, Lin SK, Lai JY, Lee BS (2011). Highly Efficient Release of Lovastatin from Poly(Lactic-co-Glycolic Acid) Nanoparticles Enhances Bone Repair in Rats. Journal of Orthopaedic Research 29(10):1504-10. (SCI)
9. Lee BS, Huang LC, Hong CY, Wang SG, Hsu WH, Yamauchi Y, Hsieh CJ, Lai JY, Wu KCW (2011). Synthesis of metal ion-histidine complex functionalized mesoporous silica nanocatalysts for enhanced light-free tooth bleaching. Acta Biomaterialia 7(5):2276-84. (SCI)
10. Lee BS, Wang CY, Fang YY, Hsieh KH, Lin CP (2011). A Novel Urethane Acrylate-based Root Canal Sealer with Improved Degree of Conversion, Cytotoxicity, Bond Strengths, Solubility, and Dimensional Stability. Journal of Endodontics 37(2):246-49. (SCI)
11. Yeh ST, Wang HT, Liao HY, Su SL, Chang CC, Kao HC, Lee BS (2011). The roughness, microhardness, and surface analysis of nanocomposites after application of topical fluoride gels. Dental Materials 27(2):187-96. (SCI)